FAS and FASL variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients.
Identifieur interne : 000239 ( Main/Exploration ); précédent : 000238; suivant : 000240FAS and FASL variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients.
Auteurs : Ericka Francislaine Dias Costa [Brésil] ; Tathiane Regine Penna Lima [Brésil] ; Leisa Lopes-Aguiar [Brésil] ; Guilherme Augusto Silva Nogueira [Brésil] ; Marília Berlofa Visacri [Brésil] ; Julia Coelho França Quintanilha [Brésil] ; Eder Carvalho Pincinato [Brésil] ; Luciane Calonga [Brésil] ; Fernanda Viviane Mariano [Brésil] ; Albina Messias De Almeida Milani Altemani [Brésil] ; João Maurício Carrasco Altemani [Brésil] ; Patrícia Moriel [Brésil] ; Carlos Takahiro Chone [Brésil] ; Celso Dario Ramos [Brésil] ; Carmen Silvia Passos Lima [Brésil]Source :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [ 1423-0380 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Alcools (effets indésirables), Antigènes CD95 (génétique), Carcinome épidermoïde de la tête et du cou (génétique), Carcinome épidermoïde de la tête et du cou (induit chimiquement), Carcinome épidermoïde de la tête et du cou (radiothérapie), Carcinome épidermoïde de la tête et du cou (traitement médicamenteux), Chimioradiothérapie (effets indésirables), Cisplatine (administration et posologie), Cisplatine (effets indésirables), Effets secondaires indésirables des médicaments (anatomopathologie), Effets secondaires indésirables des médicaments (génétique), Effets secondaires indésirables des médicaments (étiologie), Femelle (MeSH), Humains (MeSH), Ligand de Fas (génétique), Mâle (MeSH), Polymorphisme de nucléotide simple (génétique), Pronostic (MeSH), Protéine p53 suppresseur de tumeur (génétique), Sujet âgé (MeSH), Tabac (effets indésirables).
- MESH :
- administration et posologie : Cisplatine.
- anatomopathologie : Effets secondaires indésirables des médicaments.
- effets indésirables : Alcools, Chimioradiothérapie, Cisplatine, Tabac.
- génétique : Antigènes CD95, Carcinome épidermoïde de la tête et du cou, Effets secondaires indésirables des médicaments, Ligand de Fas, Polymorphisme de nucléotide simple, Protéine p53 suppresseur de tumeur.
- induit chimiquement : Carcinome épidermoïde de la tête et du cou.
- radiothérapie : Carcinome épidermoïde de la tête et du cou.
- traitement médicamenteux : Carcinome épidermoïde de la tête et du cou.
- étiologie : Effets secondaires indésirables des médicaments.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Pronostic, Sujet âgé.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Alcohols (adverse effects), Chemoradiotherapy (adverse effects), Cisplatin (administration & dosage), Cisplatin (adverse effects), Drug-Related Side Effects and Adverse Reactions (etiology), Drug-Related Side Effects and Adverse Reactions (genetics), Drug-Related Side Effects and Adverse Reactions (pathology), Fas Ligand Protein (genetics), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Polymorphism, Single Nucleotide (genetics), Prognosis (MeSH), Squamous Cell Carcinoma of Head and Neck (chemically induced), Squamous Cell Carcinoma of Head and Neck (drug therapy), Squamous Cell Carcinoma of Head and Neck (genetics), Squamous Cell Carcinoma of Head and Neck (radiotherapy), Tobacco (adverse effects), Tumor Suppressor Protein p53 (genetics), fas Receptor (genetics).
- MESH :
- chemical , administration & dosage : Cisplatin.
- chemical , adverse effects : Alcohols, Cisplatin.
- adverse effects : Chemoradiotherapy, Tobacco.
- chemically induced : Squamous Cell Carcinoma of Head and Neck.
- drug therapy : Squamous Cell Carcinoma of Head and Neck.
- etiology : Drug-Related Side Effects and Adverse Reactions.
- genetics : Drug-Related Side Effects and Adverse Reactions, Fas Ligand Protein, Polymorphism, Single Nucleotide, Squamous Cell Carcinoma of Head and Neck, Tumor Suppressor Protein p53, fas Receptor.
- pathology : Drug-Related Side Effects and Adverse Reactions.
- radiotherapy : Squamous Cell Carcinoma of Head and Neck.
- Adult, Aged, Female, Humans, Male, Middle Aged, Prognosis.
Abstract
Radiotherapy and cisplatin lead to cell killing in head and neck squamous cell carcinoma patients, but adverse events and response to treatment are not the same in patients with similar clinicopathological aspects. The aim of this prospective study was to evaluate the roles of TP53 c.215G > C, FAS c.-671A > G, FAS c.-1378G > A, FASL c.-844 C > T, CASP3 c.-1191A > G, and CASP3 c.-182-247G > T single nucleotide variants in toxicity, response rate, and survival of cisplatin chemoradiation-treated head and neck squamous cell carcinoma patients. Genomic DNA was analyzed by polymerase chain reaction for genotyping. Differences between groups of patients were analyzed by chi-square test or Fisher's exact test, multiple logistic regression analysis, and Cox hazards model. One hundred nine patients with head and neck squamous cell carcinoma were enrolled in study. All patients were smokers and/or alcoholics. Patients with FAS c.-671GG genotype, FAS c.-671AG or GG genotype, and FASL c.-844CC genotype had 5.52 (95% confidence interval (CI): 1.42-21.43), 4.03 (95% CI: 1.51-10.79), and 5.77 (95% CI: 1.23-27.04) more chances of presenting chemoradiation-related anemia of grades 2-4, lymphopenia of grade 3 or 4, and ototoxicity of all grades, respectively, than those with the remaining genotypes. FAS c.-671GG genotype was also seen as an independent predictor of shorter event-free survival (hazard ratio (HR): 2.05; P = 0.007) and overall survival (HR: 1.83; P = 0.02) in our head and neck squamous cell carcinoma patients. These findings present, for the first time, preliminary evidence that inherited abnormalities in apoptosis pathway, related to FAS c.-671A > G and FASL c.-844 C > T single nucleotide variants, can alter toxicity and survival of tobacco- and alcohol-related head and neck squamous cell carcinoma patients homogeneously treated with cisplatin chemoradiation.
DOI: 10.1177/1010428320938494
PubMed: 32628088
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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first="Tathiane Regine Penna" last="Lima">Tathiane Regine Penna Lima</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Lopes Aguiar, Leisa" sort="Lopes Aguiar, Leisa" uniqKey="Lopes Aguiar L" first="Leisa" last="Lopes-Aguiar">Leisa Lopes-Aguiar</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Internal Medicine, 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sortKey="Calonga, Luciane" sort="Calonga, Luciane" uniqKey="Calonga L" first="Luciane" last="Calonga">Luciane Calonga</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Mariano, Fernanda Viviane" sort="Mariano, Fernanda Viviane" uniqKey="Mariano F" first="Fernanda Viviane" last="Mariano">Fernanda Viviane Mariano</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Altemani, Albina Messias De Almeida Milani" sort="Altemani, Albina Messias De Almeida Milani" uniqKey="Altemani A" first="Albina Messias De Almeida Milani" last="Altemani">Albina Messias De Almeida Milani Altemani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Altemani, Joao Mauricio Carrasco" sort="Altemani, Joao Mauricio Carrasco" uniqKey="Altemani J" first="João Maurício Carrasco" last="Altemani">João Maurício Carrasco Altemani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Moriel, Patricia" sort="Moriel, Patricia" uniqKey="Moriel P" first="Patrícia" last="Moriel">Patrícia Moriel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Chone, Carlos Takahiro" sort="Chone, Carlos Takahiro" uniqKey="Chone C" first="Carlos Takahiro" last="Chone">Carlos Takahiro Chone</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Ramos, Celso Dario" sort="Ramos, Celso Dario" uniqKey="Ramos C" first="Celso Dario" last="Ramos">Celso Dario Ramos</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Lima, Carmen Silvia Passos" sort="Lima, Carmen Silvia Passos" uniqKey="Lima C" first="Carmen Silvia Passos" last="Lima">Carmen Silvia Passos Lima</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32628088</idno><idno type="pmid">32628088</idno><idno type="doi">10.1177/1010428320938494</idno><idno type="wicri:Area/Main/Corpus">000095</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000095</idno><idno type="wicri:Area/Main/Curation">000095</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000095</idno><idno type="wicri:Area/Main/Exploration">000095</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en"><i>FAS</i> and <i>FASL</i> variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients.</title><author><name sortKey="Costa, Ericka Francislaine Dias" sort="Costa, Ericka Francislaine Dias" uniqKey="Costa E" first="Ericka Francislaine Dias" last="Costa">Ericka Francislaine Dias Costa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Lima, Tathiane Regine Penna" sort="Lima, Tathiane Regine Penna" uniqKey="Lima T" first="Tathiane Regine Penna" last="Lima">Tathiane Regine Penna Lima</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Lopes Aguiar, Leisa" sort="Lopes Aguiar, Leisa" uniqKey="Lopes Aguiar L" first="Leisa" last="Lopes-Aguiar">Leisa Lopes-Aguiar</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Nogueira, Guilherme Augusto Silva" sort="Nogueira, Guilherme Augusto Silva" uniqKey="Nogueira G" first="Guilherme Augusto Silva" last="Nogueira">Guilherme Augusto Silva Nogueira</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Visacri, Marilia Berlofa" sort="Visacri, Marilia Berlofa" uniqKey="Visacri M" first="Marília Berlofa" last="Visacri">Marília Berlofa Visacri</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Quintanilha, Julia Coelho Franca" sort="Quintanilha, Julia Coelho Franca" uniqKey="Quintanilha J" first="Julia Coelho França" last="Quintanilha">Julia Coelho França Quintanilha</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Pincinato, Eder Carvalho" sort="Pincinato, Eder Carvalho" uniqKey="Pincinato E" first="Eder Carvalho" last="Pincinato">Eder Carvalho Pincinato</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Calonga, Luciane" sort="Calonga, Luciane" uniqKey="Calonga L" first="Luciane" last="Calonga">Luciane Calonga</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Mariano, Fernanda Viviane" sort="Mariano, Fernanda Viviane" uniqKey="Mariano F" first="Fernanda Viviane" last="Mariano">Fernanda Viviane Mariano</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Altemani, Albina Messias De Almeida Milani" sort="Altemani, Albina Messias De Almeida Milani" uniqKey="Altemani A" first="Albina Messias De Almeida Milani" last="Altemani">Albina Messias De Almeida Milani Altemani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Altemani, Joao Mauricio Carrasco" sort="Altemani, Joao Mauricio Carrasco" uniqKey="Altemani J" first="João Maurício Carrasco" last="Altemani">João Maurício Carrasco Altemani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Moriel, Patricia" sort="Moriel, Patricia" uniqKey="Moriel P" first="Patrícia" last="Moriel">Patrícia Moriel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Chone, Carlos Takahiro" sort="Chone, Carlos Takahiro" uniqKey="Chone C" first="Carlos Takahiro" last="Chone">Carlos Takahiro Chone</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Ramos, Celso Dario" sort="Ramos, Celso Dario" uniqKey="Ramos C" first="Celso Dario" last="Ramos">Celso Dario Ramos</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Lima, Carmen Silvia Passos" sort="Lima, Carmen Silvia Passos" uniqKey="Lima C" first="Carmen Silvia Passos" last="Lima">Carmen Silvia Passos Lima</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author></analytic><series><title level="j">Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine</title><idno type="eISSN">1423-0380</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Alcohols (adverse effects)</term><term>Chemoradiotherapy (adverse effects)</term><term>Cisplatin (administration & dosage)</term><term>Cisplatin (adverse effects)</term><term>Drug-Related Side Effects and Adverse Reactions (etiology)</term><term>Drug-Related Side Effects and Adverse Reactions (genetics)</term><term>Drug-Related Side Effects and Adverse Reactions (pathology)</term><term>Fas Ligand Protein (genetics)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Prognosis (MeSH)</term><term>Squamous Cell Carcinoma of Head and Neck (chemically induced)</term><term>Squamous Cell Carcinoma of Head and Neck (drug therapy)</term><term>Squamous Cell Carcinoma of Head and Neck (genetics)</term><term>Squamous Cell Carcinoma of Head and Neck (radiotherapy)</term><term>Tobacco (adverse effects)</term><term>Tumor Suppressor Protein p53 (genetics)</term><term>fas Receptor (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Alcools (effets indésirables)</term><term>Antigènes CD95 (génétique)</term><term>Carcinome épidermoïde de la tête et du cou (génétique)</term><term>Carcinome épidermoïde de la tête et du cou (induit chimiquement)</term><term>Carcinome épidermoïde de la tête et du cou (radiothérapie)</term><term>Carcinome épidermoïde de la tête et du cou (traitement médicamenteux)</term><term>Chimioradiothérapie (effets indésirables)</term><term>Cisplatine (administration et posologie)</term><term>Cisplatine (effets indésirables)</term><term>Effets secondaires indésirables des médicaments (anatomopathologie)</term><term>Effets secondaires indésirables des médicaments (génétique)</term><term>Effets secondaires indésirables des médicaments (étiologie)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Ligand de Fas (génétique)</term><term>Mâle (MeSH)</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Pronostic (MeSH)</term><term>Protéine p53 suppresseur de tumeur (génétique)</term><term>Sujet âgé (MeSH)</term><term>Tabac (effets indésirables)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cisplatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Alcohols</term><term>Cisplatin</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Cisplatine</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Chemoradiotherapy</term><term>Tobacco</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Squamous Cell Carcinoma of Head and Neck</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Squamous Cell Carcinoma of Head and Neck</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Alcools</term><term>Chimioradiothérapie</term><term>Cisplatine</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term><term>Fas Ligand Protein</term><term>Polymorphism, Single Nucleotide</term><term>Squamous Cell Carcinoma of Head and Neck</term><term>Tumor Suppressor Protein p53</term><term>fas Receptor</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes CD95</term><term>Carcinome épidermoïde de la tête et du cou</term><term>Effets secondaires indésirables des médicaments</term><term>Ligand de Fas</term><term>Polymorphisme de nucléotide simple</term><term>Protéine p53 suppresseur de tumeur</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Carcinome épidermoïde de la tête et du cou</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Squamous Cell Carcinoma of Head and Neck</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Carcinome épidermoïde de la tête et du cou</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome épidermoïde de la tête et du cou</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pronostic</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Radiotherapy and cisplatin lead to cell killing in head and neck squamous cell carcinoma patients, but adverse events and response to treatment are not the same in patients with similar clinicopathological aspects. The aim of this prospective study was to evaluate the roles of <i>TP53</i> c.215G > C, <i>FAS</i> c.-671A > G, <i>FAS</i> c.-1378G > A, <i>FASL</i> c.-844 C > T, <i>CASP3</i> c.-1191A > G, and <i>CASP3</i> c.-182-247G > T single nucleotide variants in toxicity, response rate, and survival of cisplatin chemoradiation-treated head and neck squamous cell carcinoma patients. Genomic DNA was analyzed by polymerase chain reaction for genotyping. Differences between groups of patients were analyzed by chi-square test or Fisher's exact test, multiple logistic regression analysis, and Cox hazards model. One hundred nine patients with head and neck squamous cell carcinoma were enrolled in study. All patients were smokers and/or alcoholics. Patients with <i>FAS</i> c.-671GG genotype, <i>FAS</i> c.-671AG or GG genotype, and <i>FASL</i> c.-844CC genotype had 5.52 (95% confidence interval (CI): 1.42-21.43), 4.03 (95% CI: 1.51-10.79), and 5.77 (95% CI: 1.23-27.04) more chances of presenting chemoradiation-related anemia of grades 2-4, lymphopenia of grade 3 or 4, and ototoxicity of all grades, respectively, than those with the remaining genotypes. <i>FAS</i> c.-671GG genotype was also seen as an independent predictor of shorter event-free survival (hazard ratio (HR): 2.05; <i>P</i> <i>=</i> 0.007) and overall survival (HR: 1.83; <i>P</i> <i>=</i> 0.02) in our head and neck squamous cell carcinoma patients. These findings present, for the first time, preliminary evidence that inherited abnormalities in apoptosis pathway, related to <i>FAS</i> c.-671A > G and <i>FASL</i> c.-844 C > T single nucleotide variants, can alter toxicity and survival of tobacco- and alcohol-related head and neck squamous cell carcinoma patients homogeneously treated with cisplatin chemoradiation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32628088</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>15</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1423-0380</ISSN><JournalIssue CitedMedium="Internet"><Volume>42</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine</Title><ISOAbbreviation>Tumour Biol</ISOAbbreviation></Journal><ArticleTitle><i>FAS</i> and <i>FASL</i> variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients.</ArticleTitle><Pagination><MedlinePgn>1010428320938494</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/1010428320938494</ELocationID><Abstract><AbstractText>Radiotherapy and cisplatin lead to cell killing in head and neck squamous cell carcinoma patients, but adverse events and response to treatment are not the same in patients with similar clinicopathological aspects. The aim of this prospective study was to evaluate the roles of <i>TP53</i> c.215G > C, <i>FAS</i> c.-671A > G, <i>FAS</i> c.-1378G > A, <i>FASL</i> c.-844 C > T, <i>CASP3</i> c.-1191A > G, and <i>CASP3</i> c.-182-247G > T single nucleotide variants in toxicity, response rate, and survival of cisplatin chemoradiation-treated head and neck squamous cell carcinoma patients. Genomic DNA was analyzed by polymerase chain reaction for genotyping. Differences between groups of patients were analyzed by chi-square test or Fisher's exact test, multiple logistic regression analysis, and Cox hazards model. One hundred nine patients with head and neck squamous cell carcinoma were enrolled in study. All patients were smokers and/or alcoholics. Patients with <i>FAS</i> c.-671GG genotype, <i>FAS</i> c.-671AG or GG genotype, and <i>FASL</i> c.-844CC genotype had 5.52 (95% confidence interval (CI): 1.42-21.43), 4.03 (95% CI: 1.51-10.79), and 5.77 (95% CI: 1.23-27.04) more chances of presenting chemoradiation-related anemia of grades 2-4, lymphopenia of grade 3 or 4, and ototoxicity of all grades, respectively, than those with the remaining genotypes. <i>FAS</i> c.-671GG genotype was also seen as an independent predictor of shorter event-free survival (hazard ratio (HR): 2.05; <i>P</i> <i>=</i> 0.007) and overall survival (HR: 1.83; <i>P</i> <i>=</i> 0.02) in our head and neck squamous cell carcinoma patients. These findings present, for the first time, preliminary evidence that inherited abnormalities in apoptosis pathway, related to <i>FAS</i> c.-671A > G and <i>FASL</i> c.-844 C > T single nucleotide variants, can alter toxicity and survival of tobacco- and alcohol-related head and neck squamous cell carcinoma patients homogeneously treated with cisplatin chemoradiation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Costa</LastName><ForeName>Ericka Francislaine Dias</ForeName><Initials>EFD</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lima</LastName><ForeName>Tathiane Regine Penna</ForeName><Initials>TRP</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lopes-Aguiar</LastName><ForeName>Leisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nogueira</LastName><ForeName>Guilherme Augusto Silva</ForeName><Initials>GAS</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Visacri</LastName><ForeName>Marília Berlofa</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quintanilha</LastName><ForeName>Julia Coelho França</ForeName><Initials>JCF</Initials><AffiliationInfo><Affiliation>Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pincinato</LastName><ForeName>Eder Carvalho</ForeName><Initials>EC</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calonga</LastName><ForeName>Luciane</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mariano</LastName><ForeName>Fernanda Viviane</ForeName><Initials>FV</Initials><AffiliationInfo><Affiliation>Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Altemani</LastName><ForeName>Albina Messias de Almeida Milani</ForeName><Initials>AMAM</Initials><AffiliationInfo><Affiliation>Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Altemani</LastName><ForeName>João Maurício Carrasco</ForeName><Initials>JMC</Initials><AffiliationInfo><Affiliation>Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moriel</LastName><ForeName>Patrícia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chone</LastName><ForeName>Carlos Takahiro</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramos</LastName><ForeName>Celso Dario</ForeName><Initials>CD</Initials><AffiliationInfo><Affiliation>Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lima</LastName><ForeName>Carmen Silvia Passos</ForeName><Initials>CSP</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-1314-2345</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Tumour Biol</MedlineTA><NlmUniqueID>8409922</NlmUniqueID><ISSNLinking>1010-4283</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000438">Alcohols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C491901">FAS protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C505661">FASLG protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053222">Fas Ligand Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C495901">TP53 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016159">Tumor Suppressor Protein p53</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019014">fas Receptor</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q20Q21Q62J</RegistryNumber><NameOfSubstance UI="D002945">Cisplatin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000438" MajorTopicYN="N">Alcohols</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059248" MajorTopicYN="N">Chemoradiotherapy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002945" MajorTopicYN="N">Cisplatin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064420" MajorTopicYN="N">Drug-Related Side Effects and Adverse Reactions</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053222" MajorTopicYN="N">Fas Ligand Protein</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000077195" MajorTopicYN="N">Squamous Cell Carcinoma of Head and Neck</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014026" MajorTopicYN="N">Tobacco</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016159" MajorTopicYN="N">Tumor Suppressor Protein p53</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019014" MajorTopicYN="N">fas Receptor</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cisplatin</Keyword><Keyword MajorTopicYN="N">FAS</Keyword><Keyword MajorTopicYN="N">FASL</Keyword><Keyword MajorTopicYN="N">head and neck squamous cell carcinoma</Keyword><Keyword MajorTopicYN="N">single nucleotide variants</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32628088</ArticleId><ArticleId IdType="doi">10.1177/1010428320938494</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Costa, Ericka Francislaine Dias" sort="Costa, Ericka Francislaine Dias" uniqKey="Costa E" first="Ericka Francislaine Dias" last="Costa">Ericka Francislaine Dias Costa</name></region><name sortKey="Altemani, Albina Messias De Almeida Milani" sort="Altemani, Albina Messias De Almeida Milani" uniqKey="Altemani A" first="Albina Messias De Almeida Milani" last="Altemani">Albina Messias De Almeida Milani Altemani</name><name sortKey="Altemani, Joao Mauricio Carrasco" sort="Altemani, Joao Mauricio Carrasco" uniqKey="Altemani J" first="João Maurício Carrasco" last="Altemani">João Maurício Carrasco Altemani</name><name sortKey="Calonga, Luciane" sort="Calonga, Luciane" uniqKey="Calonga L" first="Luciane" last="Calonga">Luciane Calonga</name><name sortKey="Chone, Carlos Takahiro" sort="Chone, Carlos Takahiro" uniqKey="Chone C" first="Carlos Takahiro" last="Chone">Carlos Takahiro Chone</name><name sortKey="Lima, Carmen Silvia Passos" sort="Lima, Carmen Silvia Passos" uniqKey="Lima C" first="Carmen Silvia Passos" last="Lima">Carmen Silvia Passos Lima</name><name sortKey="Lima, Tathiane Regine Penna" sort="Lima, Tathiane Regine Penna" uniqKey="Lima T" first="Tathiane Regine Penna" last="Lima">Tathiane Regine Penna Lima</name><name sortKey="Lopes Aguiar, Leisa" sort="Lopes Aguiar, Leisa" uniqKey="Lopes Aguiar L" first="Leisa" last="Lopes-Aguiar">Leisa Lopes-Aguiar</name><name sortKey="Mariano, Fernanda Viviane" sort="Mariano, Fernanda Viviane" uniqKey="Mariano F" first="Fernanda Viviane" last="Mariano">Fernanda Viviane Mariano</name><name sortKey="Moriel, Patricia" sort="Moriel, Patricia" uniqKey="Moriel P" first="Patrícia" last="Moriel">Patrícia Moriel</name><name sortKey="Nogueira, Guilherme Augusto Silva" sort="Nogueira, Guilherme Augusto Silva" uniqKey="Nogueira G" first="Guilherme Augusto Silva" last="Nogueira">Guilherme Augusto Silva Nogueira</name><name sortKey="Pincinato, Eder Carvalho" sort="Pincinato, Eder Carvalho" uniqKey="Pincinato E" first="Eder Carvalho" last="Pincinato">Eder Carvalho Pincinato</name><name sortKey="Quintanilha, Julia Coelho Franca" sort="Quintanilha, Julia Coelho Franca" uniqKey="Quintanilha J" first="Julia Coelho França" last="Quintanilha">Julia Coelho França Quintanilha</name><name sortKey="Ramos, Celso Dario" sort="Ramos, Celso Dario" uniqKey="Ramos C" first="Celso Dario" last="Ramos">Celso Dario Ramos</name><name sortKey="Visacri, Marilia Berlofa" sort="Visacri, Marilia Berlofa" uniqKey="Visacri M" first="Marília Berlofa" last="Visacri">Marília Berlofa Visacri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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